Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide

Yang Yang; Bingyin Shuai

doi:doi:10.11648/j.am.20231201.11

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Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide

Yang Yang, Bingyin Shuai

Published in Advances in Materials (Volume 12, Issue 1)

Received: 4 December 2022 Accepted: 27 December 2022 Published: 10 January 2023

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Abstract

Conventional therapeutic methods for organ and tissue deficiencies include surgical reconstruction, organ transplantation, medical devices treatment, synthetic prosthesis and so on, of which the application is limited when donors exhibit a low availability and impaired organs and tissues cannot well perform their functions. Tissue Engineering (TE) can harmonize with regional organs or tissues, ensure optimal degradation time for novel structure rebirth, facilitate cell adhesiveness, contribute to cell procreation and differentiation in tissue scaffolds, etc., making it an alternative option for treating pathological obstacles. Artificial polymers such as polycaprolactone (PCL) and nature materials such as peptides are adopted for the fabrication of nanofiber scaffolds. The study first engineered porous PCL scaffolds for examining the fiber morphology and the diameter alternations considering the change of single variable condition of the solution concentration, voltage and electrode distance, etc., thereby finding the basic conditions for producing nanofiber scaffolds with good formation. With the increase in solution concentration, the more obvious molecule entanglement can limit the jet stretching, thereby enlarging the fiber diameters. Voltage negatively impacts the fiber diameters, and elevated voltage can strengthen the electric intensity, thereby leading to a complete stretching of cone jets and making fiber diameters thinner. Besides, increased electrode distance is followed by expanded flight distance and decreased electrode intensity (constant voltage), as a result, fibers become narrower. Nanofiber substance exhibits the optimal performance under the condition of solution concentration: 6%, voltage: 50kV, and electrode distance: 150mm. Subsequently, nanofiber scaffolds were fabricated based on the respective preparation of PCL/P11-4 and PCL/P11-8 polymer solutions. Both P11-4 and P11-8 presented uneven distribution in PCL scaffolds, which involved various PCL nanofiber substances with abundant peptides. PCL nanofiber scaffolds saw the breakage of P11-4 and P11-8 fibers.

Published in	Advances in Materials (Volume 12, Issue 1)
DOI	10.11648/j.am.20231201.11
Page(s)	1-8
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Tissue Engineering, Polycaprolactone, Peptides, Nanofiber Scaffolds

References

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APA Style

Yang Yang, Bingyin Shuai. (2023). Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide. Advances in Materials, 12(1), 1-8. https://doi.org/10.11648/j.am.20231201.11

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ACS Style

Yang Yang; Bingyin Shuai. Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide. Adv. Mater. 2023, 12(1), 1-8. doi: 10.11648/j.am.20231201.11

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AMA Style

Yang Yang, Bingyin Shuai. Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide. Adv Mater. 2023;12(1):1-8. doi: 10.11648/j.am.20231201.11

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@article{10.11648/j.am.20231201.11,
  author = {Yang Yang and Bingyin Shuai},
  title = {Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide},
  journal = {Advances in Materials},
  volume = {12},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.am.20231201.11},
  url = {https://doi.org/10.11648/j.am.20231201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.am.20231201.11},
  abstract = {Conventional therapeutic methods for organ and tissue deficiencies include surgical reconstruction, organ transplantation, medical devices treatment, synthetic prosthesis and so on, of which the application is limited when donors exhibit a low availability and impaired organs and tissues cannot well perform their functions. Tissue Engineering (TE) can harmonize with regional organs or tissues, ensure optimal degradation time for novel structure rebirth, facilitate cell adhesiveness, contribute to cell procreation and differentiation in tissue scaffolds, etc., making it an alternative option for treating pathological obstacles. Artificial polymers such as polycaprolactone (PCL) and nature materials such as peptides are adopted for the fabrication of nanofiber scaffolds. The study first engineered porous PCL scaffolds for examining the fiber morphology and the diameter alternations considering the change of single variable condition of the solution concentration, voltage and electrode distance, etc., thereby finding the basic conditions for producing nanofiber scaffolds with good formation. With the increase in solution concentration, the more obvious molecule entanglement can limit the jet stretching, thereby enlarging the fiber diameters. Voltage negatively impacts the fiber diameters, and elevated voltage can strengthen the electric intensity, thereby leading to a complete stretching of cone jets and making fiber diameters thinner. Besides, increased electrode distance is followed by expanded flight distance and decreased electrode intensity (constant voltage), as a result, fibers become narrower. Nanofiber substance exhibits the optimal performance under the condition of solution concentration: 6%, voltage: 50kV, and electrode distance: 150mm. Subsequently, nanofiber scaffolds were fabricated based on the respective preparation of PCL/P11-4 and PCL/P11-8 polymer solutions. Both P11-4 and P11-8 presented uneven distribution in PCL scaffolds, which involved various PCL nanofiber substances with abundant peptides. PCL nanofiber scaffolds saw the breakage of P11-4 and P11-8 fibers.},
 year = {2023}
}

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TY  - JOUR
T1  - Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide
AU  - Yang Yang
AU  - Bingyin Shuai
Y1  - 2023/01/10
PY  - 2023
N1  - https://doi.org/10.11648/j.am.20231201.11
DO  - 10.11648/j.am.20231201.11
T2  - Advances in Materials
JF  - Advances in Materials
JO  - Advances in Materials
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2327-252X
UR  - https://doi.org/10.11648/j.am.20231201.11
AB  - Conventional therapeutic methods for organ and tissue deficiencies include surgical reconstruction, organ transplantation, medical devices treatment, synthetic prosthesis and so on, of which the application is limited when donors exhibit a low availability and impaired organs and tissues cannot well perform their functions. Tissue Engineering (TE) can harmonize with regional organs or tissues, ensure optimal degradation time for novel structure rebirth, facilitate cell adhesiveness, contribute to cell procreation and differentiation in tissue scaffolds, etc., making it an alternative option for treating pathological obstacles. Artificial polymers such as polycaprolactone (PCL) and nature materials such as peptides are adopted for the fabrication of nanofiber scaffolds. The study first engineered porous PCL scaffolds for examining the fiber morphology and the diameter alternations considering the change of single variable condition of the solution concentration, voltage and electrode distance, etc., thereby finding the basic conditions for producing nanofiber scaffolds with good formation. With the increase in solution concentration, the more obvious molecule entanglement can limit the jet stretching, thereby enlarging the fiber diameters. Voltage negatively impacts the fiber diameters, and elevated voltage can strengthen the electric intensity, thereby leading to a complete stretching of cone jets and making fiber diameters thinner. Besides, increased electrode distance is followed by expanded flight distance and decreased electrode intensity (constant voltage), as a result, fibers become narrower. Nanofiber substance exhibits the optimal performance under the condition of solution concentration: 6%, voltage: 50kV, and electrode distance: 150mm. Subsequently, nanofiber scaffolds were fabricated based on the respective preparation of PCL/P11-4 and PCL/P11-8 polymer solutions. Both P11-4 and P11-8 presented uneven distribution in PCL scaffolds, which involved various PCL nanofiber substances with abundant peptides. PCL nanofiber scaffolds saw the breakage of P11-4 and P11-8 fibers.
VL  - 12
IS  - 1
ER  -

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Author Information

Yang Yang

Zhejiang Yunmao Technology Co., Ltd., Hangzhou, China
Bingyin Shuai

Zhejiang Runfeng Energy Group Co., Ltd., Hangzhou, China

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APA Style

Yang Yang, Bingyin Shuai. (2023). Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide. Advances in Materials, 12(1), 1-8. https://doi.org/10.11648/j.am.20231201.11

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ACS Style

Yang Yang; Bingyin Shuai. Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide. Adv. Mater. 2023, 12(1), 1-8. doi: 10.11648/j.am.20231201.11

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AMA Style

Yang Yang, Bingyin Shuai. Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide. Adv Mater. 2023;12(1):1-8. doi: 10.11648/j.am.20231201.11

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@article{10.11648/j.am.20231201.11,
  author = {Yang Yang and Bingyin Shuai},
  title = {Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide},
  journal = {Advances in Materials},
  volume = {12},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.am.20231201.11},
  url = {https://doi.org/10.11648/j.am.20231201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.am.20231201.11},
  abstract = {Conventional therapeutic methods for organ and tissue deficiencies include surgical reconstruction, organ transplantation, medical devices treatment, synthetic prosthesis and so on, of which the application is limited when donors exhibit a low availability and impaired organs and tissues cannot well perform their functions. Tissue Engineering (TE) can harmonize with regional organs or tissues, ensure optimal degradation time for novel structure rebirth, facilitate cell adhesiveness, contribute to cell procreation and differentiation in tissue scaffolds, etc., making it an alternative option for treating pathological obstacles. Artificial polymers such as polycaprolactone (PCL) and nature materials such as peptides are adopted for the fabrication of nanofiber scaffolds. The study first engineered porous PCL scaffolds for examining the fiber morphology and the diameter alternations considering the change of single variable condition of the solution concentration, voltage and electrode distance, etc., thereby finding the basic conditions for producing nanofiber scaffolds with good formation. With the increase in solution concentration, the more obvious molecule entanglement can limit the jet stretching, thereby enlarging the fiber diameters. Voltage negatively impacts the fiber diameters, and elevated voltage can strengthen the electric intensity, thereby leading to a complete stretching of cone jets and making fiber diameters thinner. Besides, increased electrode distance is followed by expanded flight distance and decreased electrode intensity (constant voltage), as a result, fibers become narrower. Nanofiber substance exhibits the optimal performance under the condition of solution concentration: 6%, voltage: 50kV, and electrode distance: 150mm. Subsequently, nanofiber scaffolds were fabricated based on the respective preparation of PCL/P11-4 and PCL/P11-8 polymer solutions. Both P11-4 and P11-8 presented uneven distribution in PCL scaffolds, which involved various PCL nanofiber substances with abundant peptides. PCL nanofiber scaffolds saw the breakage of P11-4 and P11-8 fibers.},
 year = {2023}
}

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TY  - JOUR
T1  - Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide
AU  - Yang Yang
AU  - Bingyin Shuai
Y1  - 2023/01/10
PY  - 2023
N1  - https://doi.org/10.11648/j.am.20231201.11
DO  - 10.11648/j.am.20231201.11
T2  - Advances in Materials
JF  - Advances in Materials
JO  - Advances in Materials
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2327-252X
UR  - https://doi.org/10.11648/j.am.20231201.11
AB  - Conventional therapeutic methods for organ and tissue deficiencies include surgical reconstruction, organ transplantation, medical devices treatment, synthetic prosthesis and so on, of which the application is limited when donors exhibit a low availability and impaired organs and tissues cannot well perform their functions. Tissue Engineering (TE) can harmonize with regional organs or tissues, ensure optimal degradation time for novel structure rebirth, facilitate cell adhesiveness, contribute to cell procreation and differentiation in tissue scaffolds, etc., making it an alternative option for treating pathological obstacles. Artificial polymers such as polycaprolactone (PCL) and nature materials such as peptides are adopted for the fabrication of nanofiber scaffolds. The study first engineered porous PCL scaffolds for examining the fiber morphology and the diameter alternations considering the change of single variable condition of the solution concentration, voltage and electrode distance, etc., thereby finding the basic conditions for producing nanofiber scaffolds with good formation. With the increase in solution concentration, the more obvious molecule entanglement can limit the jet stretching, thereby enlarging the fiber diameters. Voltage negatively impacts the fiber diameters, and elevated voltage can strengthen the electric intensity, thereby leading to a complete stretching of cone jets and making fiber diameters thinner. Besides, increased electrode distance is followed by expanded flight distance and decreased electrode intensity (constant voltage), as a result, fibers become narrower. Nanofiber substance exhibits the optimal performance under the condition of solution concentration: 6%, voltage: 50kV, and electrode distance: 150mm. Subsequently, nanofiber scaffolds were fabricated based on the respective preparation of PCL/P11-4 and PCL/P11-8 polymer solutions. Both P11-4 and P11-8 presented uneven distribution in PCL scaffolds, which involved various PCL nanofiber substances with abundant peptides. PCL nanofiber scaffolds saw the breakage of P11-4 and P11-8 fibers.
VL  - 12
IS  - 1
ER  -

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